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Shocking Truth About Your Gut Microbiome Affecting Your Eyes

Sometimes we tend to take our bodies for granted,  but if we recognized the sophisticated  inner workings that go into them, we would treat them with greater respect. Since  the eye is our second most complex organ after  the brain, it should come as no surprise  that we have always been fascinated by it.

This is photo of eye
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Everything in our body is connected, so  it’s no wonder that healthy vision and  a healthy brain strongly correlate  with a healthy gut. There are more than 100 trillion microorganisms in  the human gut, and they can all affect our eyes!

How does our gut  microbiome affect our eyes?

Gut Microbiome And Gut Microbiota

First, we need to understand the  gut microbiome and gut microbiota. The term “microbiome” generally refers  to the genetic makeup of bacteria, viruses, fungi, and yeast  in or around the human body. Individual microbes themselves are  commonly referred to as “microbiota.” Food, medicines, stress, and sleep habits can impact the bacteria traveling to our gut, affecting microorganisms and viruses part of the microbiome  and significantly impacting  human health and disease.

These free-living microorganisms are  involved in various physiological processes,  including nutrition, host  immunity, drug metabolism, and endocrine signaling. They are found in  the gastrointestinal tract and are shaped  by environmental and lifestyle factors,  including geography, diet, and medications. Research suggests that 70% of  our immune system is in the gut.

Microbiota’s Role In The Development And Progression Of Eye Illnesses

Some illnesses include diabetic retinopathy,  age-related macular degeneration, glaucoma, and uveitis. A study indicates that some naturally  occurring gut microbes can trigger uveitis,  a disorder causing blindness. Suppose  a healthy gut microbiota performs its  duties in digestion and immune system defense and keeps the body balanced. When the gut microbiota causes systemic  inflammation because of abnormal activity,  the body will defend itself from  the onset of numerous illnesses.

Age-Related Macular Degeneration (AMD)

Illnesses such as Age-Related  Macular Degeneration (AMD). AMD is an acquired retinal degeneration resulting in central vision impairment because of the derangement of neovascular and non-neovascular blood vessels. As the general population ages and if they are  smokers, vision impairment rapidly increases.

According to a meta-analysis, AMD was predicted to  impact roughly 200 million people globally in 2020 and about 300 million in 2040 despite significant geographic and lifestyle variations.

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Glaucoma can damage the eye’s  optic nerve and can worsen over time. A rise in internal ocular pressure is typically the cause. Glaucoma is often genetic and doesn’t appear until much later in life. The optic nerve, which transmits images to the  brain, can be harmed by increasing fluid pressure  in your eye and, within a few years, resulting  in total blindness or irreversible vision loss.

According to research, the link  between Helicobacter pylori infection, a bacteria that infects your stomach, and the  raised ocular pressure caused by glaucoma have become a trending topic of study. Research shows  that H. pylori may be a catalyst for a systemic autoimmune response, which causes a number  of inflammatory chemicals to be released.

Diabetic Retinopathy

Diabetic retinopathy is the most  general complication of diabetes  and is a severe microvascular condition. It is predicted that by 2030, there will be  nearly 200 million cases of this condition. Important insights have been made stating a  potential connection between the gut microbiome  and diabetic retinopathy. Research has shown that  critical physiological activity, like metabolized  energy and microenvironmental homeostasis,  is influenced by gut microbiota changes.


Conditions like Uveitis are also influenced by microbiome activity. It’s a common instance of eye inflammation where the middle layer of tissue of the eye  wall is impacted. Uveitis develops  unexpectedly and rapidly gets worse. Symptoms include eye pain and blurred vision. People of all ages, including children,  can be affected by the illness, which  can impair either one or both eyes.

Studies indicate that alterations in how substances pass through the intestinal wall and microbiota might influence the  severity and development of ocular  inflammation, such as uveitis.

Dry Eyes

Dry eye disease is a common ailment  that arises when your tears cannot sufficiently moisten your eyes; this might  happen for various reasons. For instance,  dry eyes may develop if your tear production is insufficient or of poor quality. The instability of the tears can cause inflammation and surface damage to the eye.

Surprisingly, abnormalities in the eye’s surface microbiota can be found similar to those in the gut microbiome. Changing the eyes’ microbiota  also impacts ocular autoimmunity and decreases the generation  of immunoglobulin deficiency.

Balance Gut Microbiome

One question remains: Can we  balance our gut microbiome? Of course! We can change the gut microbiome for the better with certain antibiotics, short-chain fatty acids, high-fiber diets, and pre and probiotics. When administered in the correct dosage form, they help to  balance and normalize the gut microbiome.

Antibiotics: Antibiotics are the most obvious way to change the bacteria in the gut. Based on animal experiments, if you use targeted  antibiotics to change the bacteria in the gut, you can dramatically reduce the  severity of autoimmune diseases.  Increasingly, more evidence  shows that antibiotics change how our immune systems work and how well we  can fight off infections and digest food.

Short-Chain Fatty Acids And A Diet With A Lot Of Fiber

Short-chain fatty acids and a diet with a lot  of fiber: Ongoing research shows that different diets can positively affect the microbiota, which can help reduce inflammation in the eyes. Some bacteria will become more active in the gut if you eat a lot of fiber. These bacteria make short-chain  fatty acids that help regulatory T cells develop and make it less likely that your eyes will get inflamed.

Probiotics: Some types of bacteria that live in the gut can stop inflammation from getting worse. Probiotics might change the make-up of the gut  microbiome and provide beneficial functions to the gut microbial communities. This could improve  gut inflammation and other intestinal or systemic  disease symptoms. Maybe even outright stop them  from occurring. What we consume and how gut  bacteria alter their contents impact the structure  and operation of microbial communities in the gut. The relationship between the microorganisms in  our bodies and our eyes has recently attracted  more attention.

So, Let’s keep the conversation going with a few more eye care articles. Shall we? Read 9 Most Important Vitamins To Repair & Heal Your Eyes or 15 Foods To Boost Eye Health


There are more bacterial cells than human  cells in your body. Most of these bacteria  live in your gut and help keep you healthy in important ways. Human health and disease are affected by the microbial symbionts in the gut, but only recently were linked to eye diseases. Looking at the link between gut  microbiota and eye diseases,  as well as how we might be able to fix imbalances in the gut microbiome to make  the diseases they cause less problematic.

We have discussed in detail autoimmune uveitis, diabetic retinopathy, age-related macular  degeneration, and primary open-angle glaucoma. We also discuss what we know about the new area of ophthalmology research and what studies have to say about gut microbiomes. Included are  treatments that could cure the disease, such as using antibiotics, short-chain fatty acids, a high-fiber diet, and prebiotics and probiotics.